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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which can contribute to abnormal vessel reactivity. However, testosterone in physiologic doses might even be useful in sufferers with angina , have higher ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in men with established coronary artery disease . Therefore, an interplay of endogenous factors of the patient’s threat profile as well as the testosterone dosing may be problems with whether antagonistic events occur. Moreover, testosterone has been used within the treatment of reduced muscle mass and bone density as well as anemia.
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The position testosterone might play within the improvement of cardiovascular disease has more and more turn into the subject of current interest . Anabolic androgenic steroid use has elevated over the previous decade, despite its potential for opposed results. Unfortunately, the info on the use of high dose anabolic steroids in humans are primarily offered as case reports or small studies that lack enough control teams. In addition, the information available in the literature doesn’t account for the steroid type or dose, as neither could also be recognized.
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